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Thymulin

Not FDA Approved✓ WADA Permitted

Thymic Factor / Nonapeptide E / Facteur Thymique Serique (FTS)

immune○ExperimentalZinc-dependent thymic nonapeptide

Zinc-dependent nonapeptide produced by thymic epithelial cells. Essential for T-cell maturation and differentiation. Declines with age (thymic involution). Restores immune function in aged and immunocompromised models. Requires zinc for biological activity. Studied in autoimmune diseases and immune senescence.

Confidence

38%

Half-Life ~15 minutes

Cost ~$500/mo

Quick Reference

Routesubcutaneous

MechanismRequires zinc ion for biological activity (zinc-thymulin complex). Acts on thymi...

SequenceGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn

Mol. Weight859.83 Da

Reviewed2026-08-08

Mechanism of Action

Requires zinc ion for biological activity (zinc-thymulin complex). Acts on thymic and peripheral T cells → enhances T-cell differentiation, IL-2 production, and NK cell activity. Modulates Th1/Th2 balance. Binds to specific receptors on lymphocytes. Influences neuroendocrine-immune axis (bidirectional communication with hypothalamus-pituitary).

Dosing Protocol

50-100mg SC daily (note: mg dosing, not mcg) for 10-14 days per course. Zinc supplementation required concurrently. Repeat courses every 3-6 months.

Key Studies

1988

Thymulin: zinc-dependent thymic hormone

PMID 3065114review

2006

Thymic peptides in aging and immune restoration

PMID 16260427review

2015

Khavinson peptides: thymulin and immunosenescence

PMID 26340267review

Adverse Effects

Very well toleratedInjection site reactions (rare)Requires zinc co-administrationNo serious adverse events reported

Contraindications

Pregnancy (insufficient data)
Autoimmune conditions (relative — may modulate immune response)
Zinc deficiency must be corrected first

Storage

Lyophilized: 2-8°C. Reconstituted: use immediately. Zinc co-administration required for biological activity.

Clinical Applications

["immune_support"
"immune_modulation"
"anti_aging"
"autoimmune_modulation"]