ARIA
Library/hormonal/Sermorelin

Sermorelin

Not FDA Approved✓ WADA Permitted
hormonalClinical EvidenceGHRH analog

Synthetic form of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids. FDA-approved for diagnostic use in growth hormone deficiency. Off-label used for GH optimization, anti-aging, and body composition. Stimulates pituitary GH release in a physiological pulsatile pattern.

Confidence
91%
Half-Life ~10 minutes
Cost ~$450/mo
Quick Reference
Routesubcutaneous
MechanismBinds to GHRH receptor on pituitary somatotrophs → stimulates GH synthesis and r...
Reviewed2026-06-08

Mechanism of Action

Binds to GHRH receptor on pituitary somatotrophs → stimulates GH synthesis and release in a physiological pulsatile pattern. Preserves natural GH feedback mechanisms.

Dosing Protocol

100-300mcg subQ daily at bedtime. Cycles of 3-6 months recommended with 1-2 month breaks.

Adverse Effects

FlushingHeadacheInjection site reactionsDizzinessWater retention (rare)

Contraindications

  • Active malignancy
  • Diabetic retinopathy
  • Obstructive sleep apnea (untreated)
  • Acute critical illness

Storage

Refrigerate 2-8°C. Reconstitute with bacteriostatic water. Use within 30 days.