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Library/neuroprotection/Semax

Semax

Not FDA Approved✓ WADA Permitted

MEHFPGP / ACTH(4-10) analog

neuroprotection◈Clinical EvidenceSynthetic ACTH(4-10) fragment / Nootropic

Synthetic heptapeptide (ACTH(4-10) analog) developed at Moscow State University. Approved in Russia for stroke, TBI, cognitive disorders, and optic nerve disease. Normalizes BDNF, enhances neuroplasticity, crosses BBB via intranasal delivery. One of the most studied nootropic peptides.

Confidence
58%
Half-Life ~5-10 minutes (but prolonged pharmacological effect via BDNF upregulation)
Cost ~$400/mo
Quick Reference
Routeintranasal / subcutaneous
MechanismMelanocortin receptor partial agonist (MC4R, MC5R). Upregulates BDNF and TrkB ex...
SequenceMet-Glu-His-Phe-Pro-Gly-Pro
Mol. Weight847.94 Da
Reviewed2026-08-08

Mechanism of Action

Melanocortin receptor partial agonist (MC4R, MC5R). Upregulates BDNF and TrkB expression in hippocampus. Modulates NO/cGMP system. Enhances neuroplasticity and neurogenesis. Increases cerebral blood flow. Anti-inflammatory (reduces IL-6, TNF-α in CNS). Influences dopamine and serotonin turnover.

Dosing Protocol

Intranasal: 1% solution, 2-3 drops per nostril QID (stroke/cognitive) or BID (nootropic). SC: 500-1000μg daily. Courses of 10-15 days, repeat as needed.

Key Studies

2017

Semax in ischemic stroke: systematic review

PMID 28582550systematic_review
2016

Semax BDNF upregulation in animal models

PMID 27095352preclinical
2006

Semax in optic nerve disease

PMID 16297384clinical_trial
2011

Semax nootropic effects in healthy subjects

PMID 21525032clinical_trial

Adverse Effects

Well toleratedMild nasal irritationRare headache or dizzinessSlight agitation at high dosesNo serious adverse events reported

Contraindications

  • Hypersensitivity to peptide
  • Pregnancy (insufficient data)
  • Acute psychosis (relative)
  • MAO inhibitor use (theoretical)

Storage

Lyophilized: -20°C to 2-8°C. Reconstituted: 2-8°C, use within 7 days. Nasal solution: room temperature protected from light.

Clinical Applications

  • ["cognitive_enhancement"
  • "neuroprotection"
  • "stroke_recovery"
  • "nootropic"]