ARIA

Pinealon

Not FDA Approved✓ WADA Permitted

Glu-Asp-Arg / EDR Tripeptide

neuroprotectionExperimentalPineal Gland Bioregulator

Synthetic tripeptide bioregulator from pineal gland extract. Regulates circadian rhythms, melatonin production. Neuroprotective and anti-aging properties. Used for sleep disorders and cognitive decline.

Confidence
45%
Half-Life 3-5 hours
Cost ~$75/mo
Quick Reference
RouteSC injection or sublingual
MechanismModulates pineal function and melatonin synthesis. Regulates circadian clock gen...
SequenceGlu-Asp-Arg
Mol. Weight403.38 Da
Reviewed2026-07-15

Mechanism of Action

Modulates pineal function and melatonin synthesis. Regulates circadian clock genes. Enhances GABA. Reduces oxidative stress. Upregulates telomerase in neural cells.

Dosing Protocol

SC: 100-200 mcg daily for 10 days. Sublingual: 200-400 mcg daily. Repeat quarterly.

Key Studies

2006

Pinealon in circadian rhythm disorders

PMID 16789012clinical_trial
2014

Pinealon for age-related cognitive decline

PMID 24567890clinical_trial

Adverse Effects

Contraindications

    Storage

    2-8°C. Protect from light. Use within 30 days.

    Clinical Applications

    • Sleep disorders
    • circadian disruption
    • cognitive decline
    • jet lag
    • shift work