ARIA
Library/muscular/PEG-MGF

PEG-MGF

Not FDA Approved⛔ WADA Banned

PEGylated Mechano Growth Factor / PEG-IGF-1Ec

muscular◆EmergingPEGylated IGF-1 splice variant

PEGylated form of Mechano Growth Factor (IGF-1Ec), a splice variant of IGF-1 expressed in response to mechanical stimulation. PEGylation extends half-life from minutes to ~48-72 hours. Promotes satellite cell activation and muscle repair. WADA banned.

Confidence
32%
Half-Life ~48-72 hours (PEGylated); native MGF: ~5-10 minutes
Cost ~$700/mo
Quick Reference
Routeintramuscular (local to target muscle)
MechanismIGF-1Ec (MGF) is produced locally in muscle in response to mechanical stress. Bi...
SequencePEGylated IGF-1Ec splice variant (mechano growth factor)
Mol. Weight28000 Da
Reviewed2026-08-08

Mechanism of Action

IGF-1Ec (MGF) is produced locally in muscle in response to mechanical stress. Binds IGF-1R → activates satellite cells (muscle stem cells) → proliferation and differentiation. PEGylation prevents rapid degradation → sustained local and systemic effect. Promotes myoblast proliferation (unlike IGF-1 LR3 which promotes differentiation).

Dosing Protocol

200-400μg IM into target muscle group, 2-3x/week. Post-workout or post-injury. Cycle 4-6 weeks on, 4 weeks off.

Key Studies

2003

Mechano Growth Factor (MGF) splice variant of IGF-1

PMID 12509568original_discovery
2009

MGF and muscle regeneration mechanisms

PMID 19783655review
2011

IGF-1 isoforms in exercise and repair

PMID 21525032review

Adverse Effects

Limited human safety dataInjection site reactionsTheoretical tumor promotion (IGF-1 pathway)Hypoglycemia (mild, less than IGF-1 LR3)Muscle soreness at injection site

Contraindications

  • Active malignancy
  • Pregnancy
  • Competitive athletes (WADA banned)
  • Diabetes (hypoglycemia risk)

Storage

Lyophilized: -20°C for long-term storage. Reconstituted: 2-8°C, use within 14 days. Do not freeze after reconstitution.

Clinical Applications

  • ["muscle_repair"
  • "post_surgical_recovery"
  • "muscle_growth"]