ARIA
Library/skin aesthetic/Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1

Not FDA Approved✓ WADA Permitted
skin aestheticClinical EvidenceCollagen-stimulating peptide

Collagen-stimulating peptide used in cosmetic and clinical dermatology. Palmitoyl modification allows penetration through lipid bilayers. Signals fibroblasts to produce collagen types I, III, and IV. Used topically and via mesotherapy for skin rejuvenation and wound healing.

Confidence
75%
Half-Life ~hours
Cost ~$200/mo
Quick Reference
Routetopical / mesotherapy
MechanismPalmitoyl group enables penetration through lipid bilayers. Signals fibroblasts ...
Reviewed2026-06-08

Mechanism of Action

Palmitoyl group enables penetration through lipid bilayers. Signals fibroblasts to produce collagen types I, III, and IV. Stimulates extracellular matrix production.

Dosing Protocol

Mesotherapy: 2-4% solution injected intradermally every 2-4 weeks. Topical: 2-5% in serum applied twice daily.

Adverse Effects

Very well toleratedRare skin irritationNo systemic effects

Contraindications

  • Active skin infections at treatment site

Storage

Room temperature. Protect from direct sunlight.