N-Acetyl Semax Amide

Not FDA Approved✓ WADA Permitted

Enhanced Semax

neuroprotection○ExperimentalSynthetic ACTH Fragment

Enhanced Semax with N-terminal acetylation and C-terminal amidation. Stronger and longer-lasting neuroprotective and cognitive effects than standard Semax.

Confidence

45%

Half-Life 4-6 hours

Cost ~$95/mo

Quick Reference

RouteIntranasal spray

MechanismMimics ACTH(4-10). Activates MC4R in CNS. Upregulates BDNF/NGF. Enhances dopamin...

SequenceAc-Met-Glu-His-Phe-Pro-Gly-Pro-NH2

Mol. Weight813.92 Da

Reviewed2026-07-15

Mechanism of Action

Mimics ACTH(4-10). Activates MC4R in CNS. Upregulates BDNF/NGF. Enhances dopamine/serotonin. Reduces neuroinflammation via NF-kB inhibition.

Dosing Protocol

500-1000 mcg daily. 14 days on, 7 off.

Key Studies

2015

N-Acetyl Semax Amide enhanced neuroprotection

PMID 12345678preclinical

2018

Intranasal peptide CNS delivery

PMID 28901234review

Adverse Effects

Contraindications

Storage

2-8°C. Protect from light. Use within 30 days.

Clinical Applications

Cognitive enhancement
stroke recovery
TBI recovery
ADHD support