ARIA

Melanotan II

Not FDA Approved⛔ WADA Banned
sexual wellnessEmergingMelanocortin receptor agonist

Synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). Originally developed at University of Arizona as a sunless tanning agent. Found to cause spontaneous erections in male trial subjects, leading to development for erectile dysfunction. Also promotes skin pigmentation via melanocortin-1 receptor activation.

Confidence
72%
Half-Life ~2 hours
Cost ~$250/mo
Quick Reference
Routesubcutaneous
MechanismActivates melanocortin receptors (MC1R for pigmentation, MC4R for sexual functio...
Reviewed2026-06-08

Mechanism of Action

Activates melanocortin receptors (MC1R for pigmentation, MC4R for sexual function). Stimulates melanin production and modulates sexual arousal pathways.

Dosing Protocol

0.5-1mg subQ daily for tanning; 0.25-0.5mg as needed for sexual effects. Do not exceed 2mg/day.

Adverse Effects

Nausea (very common, 60%)FlushingSpontaneous erections (males)Appetite suppressionNew/darkening of moles (monitor)

Contraindications

  • Melanoma history
  • Cardiovascular disease
  • Uncontrolled hypertension
  • Pregnancy
  • Existing skin lesions

Storage

Refrigerate 2-8°C. Protect from light. Reconstitute with bacteriostatic water.