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Matrixyl 3000

Not FDA Approved✓ WADA Permitted

Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7

skin aestheticClinical EvidenceMatrikine Peptide Complex

Combination of two matrikine peptides that work synergistically to reduce wrinkles, improve skin firmness, and stimulate collagen production. Matrixyl 3000 is one of the most clinically validated anti-aging cosmetic ingredients.

Confidence
70%
Half-Life 6-8 hours (topical)
Cost ~$55/mo
Quick Reference
RouteTopical application
MechanismPal-GHK stimulates collagen I, III, and fibronectin synthesis. Pal-GQPR (Tetrape...
Reviewed2026-07-15

Mechanism of Action

Pal-GHK stimulates collagen I, III, and fibronectin synthesis. Pal-GQPR (Tetrapeptide-7) reduces IL-6 and other inflammatory cytokines. Together they promote extracellular matrix repair while reducing inflammation-driven skin aging.

Dosing Protocol

Topical: 2-8% concentration in serum/cream twice daily.

Key Studies

2007

Matrixyl in skin aging: clinical evidence

PMID 17382427clinical_trial
2011

Matrikine peptides in cosmetic dermatology

PMID 22072148review
2017

Matrixyl 3000 vs retinol comparative study

PMID 29194444clinical_trial

Adverse Effects

Contraindications

    Storage

    Room temperature. Protect from light and moisture.

    Clinical Applications

    • Wrinkle reduction
    • skin firming
    • anti-aging skincare
    • post-procedure skin care