ARIA
Library/muscular/IGF-1 LR3

IGF-1 LR3

Not FDA Approved⛔ WADA Banned

Long R3 IGF-1 / IGF-1 Long Arginine 3

muscular◆EmergingInsulin-like Growth Factor-1 analog

Modified IGF-1 with 13-amino acid extension (Long) and Arg substitution at position 3 (R3). 10x longer half-life than native IGF-1 (~20-30 hrs vs ~12 hrs). Reduced binding to IGFBPs → enhanced bioavailability. Promotes muscle growth, tissue repair, neuroprotection.

Confidence
40%
Half-Life ~20-30 hours
Cost ~$600/mo
Quick Reference
Routesubcutaneous / intramuscular
MechanismBinds IGF-1 receptor (IGF-1R) → PI3K/Akt and MAPK/ERK signaling → proliferation,...
SequenceMGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Mol. Weight9200 Da
Reviewed2026-08-08

Mechanism of Action

Binds IGF-1 receptor (IGF-1R) → PI3K/Akt and MAPK/ERK signaling → proliferation, differentiation, anti-apapoptosis. Reduced affinity for IGF-binding proteins (IGFBPs) → 10x longer half-life. Synergizes with GH (GH increases IGF-1 production). Promotes satellite cell activation. Neuroprotection via Akt pathway.

Dosing Protocol

20-120μg SC/IM daily. Bodybuilding: 50-80μg/day for 4-6 weeks on / 4-6 weeks off. Clinical: weight-based 50-100μg daily. Post-injection: may consume protein within 30 min to support signaling.

Key Studies

2003

IGF-1 LR3 pharmacokinetics vs native IGF-1

PMID 14523025pharmacology
2010

IGF-1 isoforms in muscle regeneration

PMID 20926418review
2008

IGF-1 LR3 and neurotrophic effects

PMID 18476848preclinical

Adverse Effects

Hypoglycemia (risk within 20min of injection)Injection site reactionsWater retentionOrgan enlargement (with prolonged use)Theoretical tumor promotionJoint painCarpal tunnel

Contraindications

  • Active malignancy
  • Pregnancy
  • Competitive athletes (WADA banned)
  • Diabetic patients (hypoglycemia risk)
  • Closed epiphyses in adolescents

Storage

Reconstituted: 2-8°C, use within 21 days. Do not freeze. Bacteriostatic water recommended for reconstitution.

Clinical Applications

  • ["muscle_growth"
  • "tissue_repair"
  • "neuroprotection"
  • "recovery"]