ARIA
Library/hormonal/Hexarelin

Hexarelin

Not FDA Approved⛔ WADA Banned

HEX / EP-23905 / Examorelin

hormonal◆EmergingGrowth hormone secretagogue / Ghrelin receptor agonist

Synthetic hexapeptide GH secretagogue, the most potent GHRP for GH release. Developed by Europeptides. Produces the largest GH pulse of any GHRP. Cardiac regenerative potential demonstrated in preclinical models. WADA banned. Significant cortisol and prolactin elevation with chronic use — limits long-term utility.

Confidence
45%
Half-Life ~60-70 minutes (longest of GHRPs)
Cost ~$250/mo
Quick Reference
Routesubcutaneous
MechanismPotent agonist at GHS-R1a → maximal GH release via Gq/11-PLC-IP3-Ca2+ pathway. A...
SequenceHis-D-2-Met-Trp-Ala-Trp-D-Phe-Lys-NH2
Mol. Weight886.04 Da
Reviewed2026-08-08

Mechanism of Action

Potent agonist at GHS-R1a → maximal GH release via Gq/11-PLC-IP3-Ca2+ pathway. Also activates cardiac CD34+ stem cells via CD36 receptor → cardiac regeneration. Elevates cortisol and prolactin (dose-dependent). Stronger GH release than GHRP-6 and GHRP-2. Desensitization occurs with chronic use (tachyphylaxis).

Dosing Protocol

100-200μg SC, 2-3x daily (fasting). Due to desensitization, limit to 4-8 week cycles with 4+ week breaks. Often paired with CJC-1295.

Key Studies

1996

Hexarelin: most potent GHRP in humans

PMID 8954017clinical_trial
1999

Hexarelin GH response vs other GHRPs

PMID 10386498clinical_trial
2008

Hexarelin cardiac regeneration in animal models

PMID 19095716preclinical
2015

GHRP metabolites in doping analysis

PMID 25869809analytical

Adverse Effects

Strongest GH pulse of any GHRPSignificant cortisol elevationSignificant prolactin elevationDesensitization with chronic use (tachyphylaxis)FlushingWater retentionInjection site reactions

Contraindications

  • Active malignancy
  • Pregnancy
  • Competitive athletes (WADA banned)
  • Hyperprolactinemia
  • Cushing's syndrome
  • Cardiac conditions (relative — despite cardiac regeneration potential)

Storage

Lyophilized: 2-8°C or frozen. Reconstituted: 2-8°C, use within 30 days. Bacteriostatic water recommended.

Clinical Applications

  • ["hormonal_optimization"
  • "gh_deficiency"
  • "cardiac_regeneration"
  • "body_composition"]