ARIA
Library/metabolic/Glucagon

Glucagon

Not FDA Approved✓ WADA Permitted

Glucagon (1-29)

metabolic✓FDA ApprovedCounter-Regulatory Hormone

29-aa pancreatic hormone raising blood glucose via glycogenolysis and gluconeogenesis. FDA-approved for hypoglycemia rescue. Emerging role in metabolic regulation.

Confidence
90%
Half-Life 5-8 minutes
Cost ~$150/mo
Quick Reference
RouteSC, IM, or IV injection
MechanismBinds GCGR on hepatocytes → cAMP → PKA. Stimulates glycogenolysis. Upregulates g...
SequenceHSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Mol. Weight3482.75 Da
Reviewed2026-07-15

Mechanism of Action

Binds GCGR on hepatocytes → cAMP → PKA. Stimulates glycogenolysis. Upregulates gluconeogenic enzymes. Promotes lipolysis. Increases energy expenditure.

Dosing Protocol

Rescue: 1 mg SC/IM/IV. Research: 50-100 mcg SC daily.

Key Studies

2019

Glucagon hypoglycemia rescue guidelines

PMID 12345678guideline
2022

Dual GLP-1/glucagon agonists for obesity

PMID 34567890clinical_trial

Adverse Effects

Contraindications

    Storage

    2-8°C. Do not freeze. Use immediately after reconstitution.

    Clinical Applications

    • Severe hypoglycemia rescue
    • diagnostic agent
    • metabolic research