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Library/anti aging/Epithalon

Epithalon

Not FDA Approved✓ WADA Permitted

Epitalon / AEDG peptide

anti aging○ExperimentalSynthetic tetrapeptide / Telomerase activator

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Vladimir Khavinson. Activates telomerase in human cells, extending replicable lifespan in vitro. Preclinical evidence for pineal epithalamin mimicry. Clinical studies show reduced mortality in elderly patients and improved melatonin regulation.

Confidence
35%
Half-Life ~15 minutes (short; rapid tissue uptake)
Cost ~$450/mo
Quick Reference
Routesubcutaneous / intranasal
MechanismMimics epithalamin (pineal gland peptide extract). Activates telomerase (TERT) i...
SequenceAla-Glu-Asp-Gly
Mol. Weight390.35 Da
Reviewed2026-08-08

Mechanism of Action

Mimics epithalamin (pineal gland peptide extract). Activates telomerase (TERT) in somatic cells → telomere maintenance. Modulates pineal melatonin secretion. Upregulates antioxidant enzymes (SOD, glutathione peroxidase). Reduces oxidative stress. May activate chromatin decondensation via N-terminal Ala-Glu tail interaction with histone H1.

Dosing Protocol

5-10mg SC daily for 10-20 days. Repeat 1-2x/year. Intranasal: 20 drops (2.5%) daily for 10-20 days per course.

Key Studies

2003

Epitalon activates telomerase in human cells

PMID 12676185in_vitro
2006

Epitalon improves melatonin in aged monkeys and humans

PMID 16260427clinical
2006

Epithalamin + thymalin reduces mortality in elderly

PMID 16519946clinical_trial
2015

Khavinson peptides: geroprotection mechanisms

PMID 26340267review

Adverse Effects

Very limited human dataTheoretical: fatigue during initial treatmentMild headacheNo serious adverse events reported in clinical studies

Contraindications

  • Active malignancy (theoretical: telomerase activation)
  • Pregnancy (insufficient data)
  • Autoimmune conditions (relative)

Storage

Lyophilized powder: 2-8°C. Reconstituted: use immediately or within 24hrs refrigerated.

Clinical Applications

  • ["anti_aging"
  • "telomere_support"
  • "melatonin_regulation"
  • "geroprotection"]