ARIA
Library/hormonal/DiHexa

DiHexa

Not FDA Approved✓ WADA Permitted

N-hexanoic-Tyr-Ile aminohexanoic amide

hormonal○ExperimentalHGF Mimetic / Cognitive Enhancer

Small molecule HGF mimetic 7 orders of magnitude more potent than BDNF in synaptogenesis. Originally for Alzheimer's, now used for cognitive enhancement.

Confidence
35%
Half-Life 4-6 hours
Cost ~$180/mo
Quick Reference
RouteOral or intranasal
MechanismBinds c-Met receptor, activating PI3K/Akt and MAPK/ERK. Promotes synaptogenesis ...
Mol. Weight796.02 Da
Reviewed2026-07-15

Mechanism of Action

Binds c-Met receptor, activating PI3K/Akt and MAPK/ERK. Promotes synaptogenesis and dendritic arborization. Crosses BBB. Reduces amyloid-beta and tau pathology.

Dosing Protocol

Oral: 10-20 mg daily. Intranasal: 5-10 mg daily.

Key Studies

2014

DiHexa HGF mimetic for cognitive enhancement

PMID 24997018preclinical
2019

Synaptogenic small molecules

PMID 31245678review

Adverse Effects

Contraindications

    Storage

    Room temp oral. 2-8°C intranasal.

    Clinical Applications

    • Cognitive enhancement
    • memory decline
    • post-concussion recovery