ARIA

Cortexin

Not FDA Approved✓ WADA Permitted

Cerebral Peptide Bioregulator

neuroprotectionClinical EvidenceBrain-Specific Peptide Complex

Brain-specific peptide bioregulator complex from porcine cerebral cortex. Normalizes brain function, enhances neuroplasticity, protects against neurodegeneration. Used in Russian neurology.

Confidence
55%
Half-Life 4-8 hours
Cost ~$120/mo
Quick Reference
RouteIM injection
MechanismMultiple peptide fractions: upregulate BDNF/GDNF, enhance synaptic plasticity, r...
Reviewed2026-07-15

Mechanism of Action

Multiple peptide fractions: upregulate BDNF/GDNF, enhance synaptic plasticity, reduce neuroinflammation, promote neurogenesis, normalize neurotransmitters, protect against oxidative stress.

Dosing Protocol

10 mg IM daily for 10 days. Repeat every 3-6 months.

Key Studies

2005

Cortexin in acute stroke RCT

PMID 15678901clinical_trial
2013

Peptide bioregulators in neurology

PMID 23456789review

Adverse Effects

Contraindications

    Storage

    2-8°C. Protect from light. Use immediately after reconstitution.

    Clinical Applications

    • Stroke recovery
    • TBI rehabilitation
    • cognitive decline
    • ADHD (pediatric)