ARIA

Carnosine

Not FDA Approved✓ WADA Permitted

Beta-Alanyl-L-Histidine

anti agingClinical EvidenceDipeptide Anti-Glycation Agent

Naturally occurring dipeptide with potent anti-glycation, antioxidant, and anti-crosslinking properties. Protects proteins from glycation damage, chelates metal ions, buffers pH. Decades of safety data.

Confidence
75%
Half-Life 2-4 hours
Cost ~$45/mo
Quick Reference
RouteOral or SC injection
MechanismScavenges reactive carbonyl species preventing AGE formation. Chelates zinc, cop...
SequenceAla-His
Mol. Weight226.23 Da
Reviewed2026-07-15

Mechanism of Action

Scavenges reactive carbonyl species preventing AGE formation. Chelates zinc, copper. Buffers pH. Inhibits protein crosslinking. Activates AMPK. Protects telomeres.

Dosing Protocol

Oral: 500-1000 mg daily. SC: 100-200 mg daily.

Key Studies

2002

Carnosine as protective factor in aging

PMID 12182961review
2015

Carnosine and diabetes systematic review

PMID 24997018meta_analysis

Adverse Effects

Contraindications

    Storage

    Room temp for oral. 2-8°C for injectable.

    Clinical Applications

    • Anti-aging
    • diabetic complications prevention
    • exercise performance
    • cognitive protection